The interest in macromolecular complexes has increased dramatically in recent years. The study of intact proteins and their function in non-covalently bound complexes is providing more information about complicated biological systems. It is well-known that large protein complexes can be transferred into the gas phase intact using nano-electrospray ionisation, but subsequent MS or MS/MS analysis is prohibited by mass-scale, ion transmission or ion thermalisation limitations on standard instrumentation.
MS Vision offer the high mass upgrade package for Q-Tof instruments, so you are now able to perform these experiments yourself without the cost of buying a new instrument. A series of modifications, designed specifically for optimal transmission and control of large ions, turns any Micromass Q-Tof 1, 2 or Ultima into a unique instrument.
For a detailed description of the modifications follow the links provided.
